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Studies have shown that one-half of adolescent girls who first begin to menstruate after age 13 will not ovulate regularly over the next four and a half years.In boys, an increase in the size of the testicles is the first change observed at the onset of puberty.Leptin, however, is likely only one of multiple influences on the hypothalamus, an area of the brain that releases a hormone known as gonadotropin-releasing hormone (Gn RH), which in turn signals the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH).LH and FSH secretion by the pituitary is responsible for sexual development.
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However, girls who have a later onset of menstruation (after age 13) tend to have lower rates of regular ovulation in the years following the onset of menstruation.One theory proposes that reaching a critical weight or body composition may play a role in the onset of puberty.
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